1/30/2024 0 Comments Salvage bed in radiation islandFind unique places to stay with local hosts in 191 countries. Further study in large, randomized trials is warranted.Ĭopyright © 2020 Elsevier Inc. 25, 2023 - Rent from people in Salvage, Canada from 27 CAD/night. Hypofractionated RT to the prostate bed in 15 treatments was safe, with an acceptable GU and GI toxicity profile. The short follow-up limits our ability to perform a robust oncologic endpoint assessment however, the 2-year BFFS, use of subsequent salvage therapy, and the development of metastasis were 95.1%, 0%, and 0%, respectively. The late grade ≥2 GI toxicity rate was 11.5%, and no grade 3 GI adverse events were reported. The late grade ≥2 GU toxicity rate was 8.2%, and 1 patient (1.6%) developed both acute and late grade 3 GU toxicity. After a median follow-up of 16 months, 11.5% of patients experienced acute grade ≥2 GU symptoms and 13.1% experienced acute grade ≥2 GI symptoms. Of 64 enrolled patients, 61 received radiation therapy (57 salvage and 4 adjuvant radiation therapy). Secondary endpoints included acute gastrointestinal (GI) and late GU/GI toxicities, biochemical failure-free survival (BFFS), metastasis-free survival, cancer-specific survival, overall survival, and health-related quality of life. The primary endpoint was the rate of acute genitourinary (GU) grade ≥2 toxicity. The prescribed dose was 51 Gy in 15 fractions (3.4 Gy per fraction), using intensity modulated and image guided radiation therapy techniques. In this phase 2 trial, patients submitted to radical prostatectomy were treated with hypofractionated RT to the prostate bed (adjuvant or salvage). We conducted a prospective trial to evaluate the safety and feasibility of postoperative hypofractionated RT to the prostate bed. Although clinical trials have established the safety and efficacy of hypofractionation as a primary therapy, there are limited data in a postoperative setting. Postoperative radiation therapy (RT) is a common therapy used for patients with prostate cancer.
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